17 Chicken breast recipes casserole

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Casseroles are the perfect comfort food — hearty, simple, and easy to prepare ahead.

These 17 chicken breast casserole recipes bring together creamy sauces, fresh vegetables, and cheesy goodness for satisfying dinners your family will love.

Each includes a detailed ingredient list and clear instructions for success every time.

1. Chicken and Rice Casserole

A creamy, hearty classic with tender chicken, rice, and rich sauce baked to perfection.

Ingredients:

  • 2 chicken breasts, diced

  • 1 cup uncooked white rice

  • 1 can cream of mushroom soup

  • 1½ cups chicken broth

  • 1 cup shredded cheddar cheese

  • Salt, pepper, garlic powder to taste

Instructions:

  1. Preheat oven to 375°F (190°C).

  2. Mix rice, soup, broth, and seasonings in a greased casserole dish.

  3. Lay chicken pieces on top and sprinkle with cheese.

  4. Cover with foil and bake 40 minutes, then uncover and bake 10 minutes more.

2. Broccoli Cheddar Chicken Casserole

Creamy and cheesy with a comforting broccoli twist.

Ingredients:

  • 2 chicken breasts, cooked and shredded

  • 2 cups broccoli florets, steamed

  • 1 can cream of chicken soup

  • 1 cup sour cream

  • 1 cup cheddar cheese

  • 1 cup crushed Ritz crackers

Instructions:

  1. Preheat oven to 350°F (175°C).

  2. Mix soup, sour cream, and cheese; fold in chicken and broccoli.

  3. Pour into a baking dish, top with crushed crackers.

  4. Bake uncovered for 25 minutes until bubbly and golden.

3. Chicken Alfredo Casserole

A creamy pasta bake loaded with Alfredo flavor.

Ingredients:

  • 2 chicken breasts, cooked and sliced

  • 8 oz fettuccine pasta

  • 2 cups Alfredo sauce

  • 1 cup mozzarella cheese

  • ½ cup grated Parmesan

  • 1 tsp Italian seasoning

Instructions:

  1. Cook pasta; drain and mix with Alfredo sauce and seasonings.

  2. Layer pasta, chicken, and cheese in a casserole dish.

  3. Bake at 375°F (190°C) for 25 minutes until bubbly.

4. Chicken Enchilada Casserole

A Mexican-inspired favorite layered with tortillas and cheese.

Ingredients:

  • 2 chicken breasts, shredded

  • 1 can enchilada sauce

  • 6 corn tortillas

  • 1 cup black beans

  • 1 cup shredded Mexican cheese blend

  • ½ cup sour cream

Instructions:

  1. Preheat oven to 375°F (190°C).

  2. Layer tortillas, chicken, beans, sauce, and cheese.

  3. Repeat layers and finish with cheese on top.

  4. Bake 30 minutes until golden and bubbling.

5. Chicken and Stuffing Casserole

Classic Thanksgiving comfort with a creamy chicken base.

Ingredients:

  • 2 chicken breasts, cooked and cubed

  • 1 can cream of chicken soup

  • 1 cup sour cream

  • 1 box stuffing mix

  • ½ cup chicken broth

Instructions:

  1. Mix soup, sour cream, and chicken in a bowl.

  2. Spread mixture in casserole dish.

  3. Prepare stuffing mix with broth, then spread on top.

  4. Bake at 350°F (175°C) for 30 minutes.

6. Buffalo Chicken Casserole

Spicy, cheesy, and packed with flavor.

Ingredients:

  • 2 chicken breasts, cooked and shredded

  • ½ cup buffalo sauce

  • 1 cup ranch dressing

  • 1½ cups shredded mozzarella

  • 1 cup cooked pasta or cauliflower rice

Instructions:

  1. Combine chicken, buffalo sauce, ranch, and mozzarella.

  2. Mix in pasta or cauliflower rice.

  3. Bake at 375°F (190°C) for 25 minutes until cheese melts.

7. Chicken Parmesan Casserole

All the flavors of chicken parm in an easy bake.

Ingredients:

  • 2 chicken breasts, sliced

  • 1 jar marinara sauce

  • 1 cup mozzarella

  • ½ cup Parmesan

  • 1 cup breadcrumbs

Instructions:

  1. Layer chicken and marinara in a baking dish.

  2. Sprinkle cheese and breadcrumbs over top.

  3. Bake at 375°F (190°C) for 30 minutes.

8. Chicken and Spinach Lasagna Casserole

A layered bake filled with spinach, ricotta, and tender chicken.

Ingredients:

  • 2 cups cooked chicken, shredded

  • 6 lasagna noodles, cooked

  • 1 cup ricotta cheese

  • 1 cup mozzarella

  • 2 cups spinach

  • 1 jar Alfredo sauce

Instructions:

  1. Layer noodles, sauce, chicken, spinach, and cheese.

  2. Repeat layers and top with mozzarella.

  3. Bake at 375°F (190°C) for 30–35 minutes.

9. Chicken Bacon Ranch Casserole

Savory, smoky, and ultra creamy.

Ingredients:

  • 2 chicken breasts, cooked and cubed

  • 1 cup pasta

  • 1 cup ranch dressing

  • ½ cup crumbled bacon

  • 1 cup shredded cheese

Instructions:

  1. Mix cooked pasta, chicken, ranch, bacon, and cheese.

  2. Pour into casserole dish and top with more cheese.

  3. Bake 25 minutes at 375°F (190°C).

10. Creamy Chicken Mushroom Casserole

Comforting mushrooms and tender chicken in a rich sauce.

Ingredients:

  • 2 chicken breasts, cubed

  • 1 can cream of mushroom soup

  • 1 cup sliced mushrooms

  • ½ cup milk

  • ½ cup shredded Swiss cheese

Instructions:

  1. Combine soup, milk, mushrooms, and cheese.

  2. Mix with chicken and pour into baking dish.

  3. Bake 30 minutes at 350°F (175°C).

11. Chicken Zucchini Casserole

A lighter, veggie-forward casserole.

Ingredients:

  • 2 chicken breasts, cooked and shredded

  • 2 cups diced zucchini

  • 1 can cream of chicken soup

  • ½ cup sour cream

  • 1 cup shredded cheddar

Instructions:

  1. Mix soup, sour cream, and chicken.

  2. Fold in zucchini and cheese.

  3. Bake at 350°F (175°C) for 25–30 minutes.

12. Chicken and Potato Bake

Hearty, filling, and loaded with flavor.

Ingredients:

  • 2 chicken breasts, cubed

  • 2 cups diced potatoes

  • 1 onion, chopped

  • 1 cup shredded cheddar

  • ½ tsp paprika

Instructions:

  1. Toss potatoes, chicken, onion, and paprika in oil.

  2. Bake 35 minutes at 400°F (200°C).

  3. Sprinkle cheese and bake another 5 minutes.

13. BBQ Chicken Casserole

Sweet and smoky barbecue flavors in a cheesy bake.

Ingredients:

  • 2 chicken breasts, cooked and shredded

  • ½ cup BBQ sauce

  • 1 cup cooked pasta

  • 1 cup shredded cheddar

  • ½ cup corn

Instructions:

  1. Mix chicken, BBQ sauce, pasta, and corn.

  2. Top with cheese and bake 25 minutes at 375°F (190°C).

14. Chicken and Veggie Tater Tot Casserole

Crispy, cheesy, and loaded with veggies.

Ingredients:

  • 2 cups cooked chicken, shredded

  • 1 can cream of chicken soup

  • 1 cup mixed vegetables

  • 1½ cups frozen tater tots

  • 1 cup shredded cheese

Instructions:

  1. Combine chicken, soup, and vegetables in dish.

  2. Top with cheese and tater tots.

  3. Bake 35 minutes at 400°F (200°C) until golden.

15. Chicken Pesto Pasta Casserole

Fresh and flavorful with basil pesto and gooey cheese.

Ingredients:

  • 2 cups cooked pasta

  • 2 chicken breasts, sliced

  • ¼ cup basil pesto

  • 1 cup mozzarella cheese

  • ½ cup cherry tomatoes

Instructions:

  1. Toss pasta and chicken with pesto.

  2. Pour into a baking dish and add cheese and tomatoes.

  3. Bake 20 minutes at 375°F (190°C).

16. Chicken Tortilla Casserole

A Tex-Mex casserole with a spicy kick.

Ingredients:

  • 2 chicken breasts, shredded

  • 1 can diced tomatoes with green chilies

  • 6 tortillas, cut into strips

  • 1 cup cheddar cheese

  • ½ cup sour cream

Instructions:

  1. Layer tortillas, chicken, tomatoes, and cheese.

  2. Repeat and top with sour cream.

  3. Bake 30 minutes at 350°F (175°C).

17. Chicken Florentine Casserole

A rich and creamy casserole with spinach and Parmesan.

Ingredients:

  • 2 chicken breasts, sliced

  • 2 cups fresh spinach

  • 1 can cream of mushroom soup

  • ½ cup milk

  • ½ cup grated Parmesan

Instructions:

  1. Mix soup, milk, and Parmesan.

  2. Layer chicken and spinach in baking dish.

  3. Pour sauce over and bake 30 minutes at 375°F (190°C).

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